Part:BBa_K4612101
CD177 _Target_2
CD177 _Target_2 (BBa_K4612101) is a single-stranded DNA sequence with 30 nucleotides and is an intercepted portion of the sequence of the gene CD177 that is guaranteed to be specific in the human body. It was screened by machine learning as a target related to bacterial infection and assigned a weight of "+4". CD177 helps mediate neutrophil migration in endothelial cells by interacting with PECAM1, which helps to allow them to reach areas of bacterial invasion [1]. And it has been shown that CD177 can be used as an indicator to recognize bacterial infection [2]. So the expression of CD177 has a role in determining whether it is a bacterial infection or not, and can be given weight. Figure 1 shows the specific function of this element: it binds to the probe as a target, and then the polymerase uses it as a primer for a polymerase-mediated strand displacement reaction. The weighted strand is then subjected to a subsequent toe-mediated strand displacement reaction to produce a fluorescent report.
Sequence and Features
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